Moe Nishinosono is infactuated with her professor Sohei Saikawa. One day she goes visit Shiki Mugata, a prodigy who gained her doctorate at the age of 11 but found to be guilty of murdering her parents one day. Yet, Mugata claims she didn't. She also happens to be held in high regard by the professor because of her high intelligence...

Sentan Island is caught in the middle of a warzone. Akiyuki looks like your everyday student rushing off to school when there is an air raid and the school bus he was on explodes. While trying to help a refugee he helped sneak onto the bus, he finds himself "Xam'd" - when a human is injected with a seed known as "Hiruko" transforming them...