According to an interview from MCV, game designer Suda51 reveals that action game No More Heroes was originally planned for the Xbox 360.

Originally, I’d wanted to make this game for Xbox 360, actually. [Marvelous Interactive boss] Wada-san had information about the new Wii and how the new controller would work before it came out, so that’s why he thought I should produce the game on that format.

“At the time, I didn’t really understand why, but after seeing and understanding how it works, I think it was a good choice and the controller works really well with the game.”

Well, the game would definitely have looked much better that's for sure with its powerful graphics chip set and HD support. On the content side of things I think it wouldn't be much different considering even the Xbox 360 is only using dual layer 8GB DVDs which the Wii is also capable of using. In other words, the developers could have added more content than the 4GB game currently offers anyway. The AI might just fair a bit better with the Xbox 360's faster processor but, that would have depended on the programmer really.

Control-wise, I think nothing could be more fun in an action game than getting to actually swing your arms to pull off that cool finishing move on the enemies or those painful wrestling moves.